Tarawneh R, D'Angelo G, Macy E, Xiong C, Carter D, Cairns NJ, Fagan AM, Head D, Mintun MA, Ladenson JH, Lee JM, Morris JC, Holtzman DM. Visinin-like protein-1: diagnostic and prognostic biomarker in Alzheimer disease. Ann Neurol. 2011 Aug;70(2):274-85. PubMed.
AlzBiomarker Database
Meta-Analysis
- AD vs CTRL : Aβ42 (CSF)
- CTRL vs AD : Aβ42 (CSF)
- AD vs CTRL : VLP-1 (CSF)
- CTRL vs AD : VLP-1 (CSF)
- AD vs CTRL : tau-p181 (CSF)
- CTRL vs AD : tau-p181 (CSF)
- AD vs CTRL : tau-total (CSF)
- CTRL vs AD : tau-total (CSF)
Curated Study Data
| Biomarker (Source) |
Cohort (N) |
Measurement Mean ± SD |
Method; Assay Name; Manufacturer |
Diagnostic Criteria |
|---|---|---|---|---|
| Aβ42 (CSF) |
AD (98) |
390 ± 175 pg/mL |
ELISA; Innotest; Innogenetics |
Morris et al., 2006; Berg et al., 1998 |
| Aβ42 (CSF) |
CTRL- CNC (211) |
615 ± 246 pg/mL |
ELISA; Innotest; Innogenetics |
|
| VLP-1 (CSF) |
AD (98) |
520 ± 171 pg/mL |
Single Molecule Counting Immunoassay; Erenna; Singulex, Inc. |
Morris et al., 2006; Berg et al., 1998 |
| VLP-1 (CSF) |
CTRL- CNC (211) |
396 ± 149 pg/mL |
Single Molecule Counting Immunoassay; Erenna; Singulex, Inc. |
|
| tau-p181 (CSF) |
AD (98) |
90 ± 42 pg/mL |
ELISA; Innotest; Innogenetics |
Morris et al., 2006; Berg et al., 1998 |
| tau-p181 (CSF) |
CTRL- CNC (211) |
54 ± 23 pg/mL |
ELISA; Innotest; Innogenetics |
|
| tau-total (CSF) |
AD (98) |
602 ± 282 pg/mL |
ELISA; Innotest; Innogenetics |
Morris et al., 2006; Berg et al., 1998 |
| tau-total (CSF) |
CTRL- CNC (211) |
295 ± 159 pg/mL |
ELISA; Innotest; Innogenetics |
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