. Using FDG PET and PIB (Pittsburgh B) PET imaging to distinguish atypical Alzheimer’s disease and fronto-temporal dementia cases. Human Amyloid Imaging 2010 Meeting Abstracts. 2010 April 9;


Background: Many cases of progressive dementia are not clinically typical for Alzheimer’s disease (AD). Frontotemporal dementia (FTD) or variants are often considered, but are by no means certain clinical diagnoses. More precise diagnosis is needed.

Methods: 35 patients were studied; 12 meeting criteria for “probable AD”, and 6 judged to be FTD or one of its variants with “high probability”. The other 17 were judged to be “atypical/possible AD/possibly FTD, and the degree of diagnostic certainly was rated as medium to low. All were studied with FDG PET, and PET amyloid imaging with PIB (Pittsburgh B Compound).

Results: Of those 12 subjects meeting criteria for “probable AD”, 11 remained classified as such after multi-modal imaging, but one was reclassified as FTD. Of the 6 patients judged to be FTD with “high certainty”, four remained as such, while two were reclassified as AD. Of the 17 rated clinically with medium to low diagnostic certainty, all were reclassified, 15 as AD, and 2 as FTD.

Conclusions: Multi-modal imaging was successful in classifying all medium and low certainty cases in a convergent manner.


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  1. Toronto: HAI Amyloid Imaging Conference Abstracts