. The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility. Cell. 2002 Oct 18;111(2):209-18. PubMed.


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  1. This provides a new insight in protein-degradation study as wellas Parkinson's Disease. It is more interesting how the varations of UCH-L1 affect both activities.

  2. A very interesting paper: I caution still, however, that a genetic role for UCH-L1 in Parkinson's is not yet established.

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