. On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells. Neurosci Lett. 2001 Nov 13;314(1-2):45-8. PubMed.


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  1. Increasing evidence suggests that elements of the cholesterol pathway regulate Abeta production. This increases the importance of understanding cholesterol metabolism and trafficking in the brain. The discovery of disease related changes in cholesterol metabolism/catabolism in the brain could provide important insights for the pathophysiological mechanism underlying AD.

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