. Tumor necrosis factor-alpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner. J Biol Chem. 2006 Jul 28;281(30):21362-8. PubMed.


Please login to recommend the paper.


  1. This article joins an increasing body of scientific evidence which suggests that TNF-alpha interactions with glutamate pathways may be involved in the pathogenesis of Alzheimer disease (see Zou et al., 2005 and additional references below).

    TNF-amyloid interactions and other known pleotropic actions of TNF-alpha may also be involved in the pathogenesis of AD (see Rosenberg, 2005 and Tobinick et al., 2006).


    . TNF alpha potentiates glutamate neurotoxicity by inhibiting glutamate uptake in organotypic brain slice cultures: neuroprotection by NF kappa B inhibition. Brain Res. 2005 Feb 9;1034(1-2):11-24. PubMed.

    . Stimulation of microglial metabotropic glutamate receptor mGlu2 triggers tumor necrosis factor alpha-induced neurotoxicity in concert with microglial-derived Fas ligand. J Neurosci. 2005 Mar 16;25(11):2952-64. PubMed.

    . Actions of TNF-alpha on glutamatergic synaptic transmission in the central nervous system. Exp Physiol. 2005 Sep;90(5):663-70. PubMed.

    . Tumor necrosis-factor-alpha (TNF-alpha) induces rapid insertion of Ca2+-permeable alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA)/kainate (Ca-A/K) channels in a subset of hippocampal pyramidal neurons. Exp Neurol. 2005 Jun;193(2):384-93. PubMed.

    . Glutamate induces the expression and release of tumor necrosis factor-alpha in cultured hypothalamic cells. Brain Res. 2005 Aug 16;1053(1-2):54-61. PubMed.

    . Beta-amyloid-stimulated microglia induce neuron death via synergistic stimulation of tumor necrosis factor alpha and NMDA receptors. J Neurosci. 2005 Mar 9;25(10):2566-75. PubMed.

    . TNFalpha-induced AMPA-receptor trafficking in CNS neurons; relevance to excitotoxicity?. Neuron Glia Biol. 2004 Aug;1(3):263-273. PubMed.

    . Clinical aspects of inflammation in Alzheimer's disease. Int Rev Psychiatry. 2005 Dec;17(6):503-14. PubMed.

    . TNF-alpha modulation for treatment of Alzheimer's disease: a 6-month pilot study. MedGenMed. 2006;8(2):25. PubMed.

Make a Comment

To make a comment you must login or register.