. Tumor necrosis factor-alpha -308A/G polymorphism is associated with age at onset of Alzheimer's disease. Mech Ageing Dev. 2006 Jun;127(6):567-71. PubMed.


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  1. This study joins a recent report from Australia (Laws et al., 2005) that associates variations in a single nucleotide that affect TNF-alpha (a single nucleotide polymorphism, or SNP) with the risk of developing Alzheimer disease. These studies, together with the recent report from the associated groups from the University of Washington and UC Davis (Ramos et al., 2006) provide further clinical evidence suggesting that TNF-alpha may be involved in AD pathogenesis.


    . TNF polymorphisms in Alzheimer disease and functional implications on CSF beta-amyloid levels. Hum Mutat. 2005 Jul;26(1):29-35. PubMed.

    . Tumor necrosis factor alpha and interleukin 10 promoter region polymorphisms and risk of late-onset Alzheimer disease. Arch Neurol. 2006 Aug;63(8):1165-9. PubMed.

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