. TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis. Sci Transl Med. 2014 Jul 2;6(243):243ra86. PubMed.


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  1. Based on a study (Nazmi et al., 2019), TREM2 expression depends upon type I IFN-signaling and the type I IFNs are associated with neuroinflammation. Therefore, it may be important to know whether localized type I IFN production in the AD brain has any measurable effect on the levels of sTREM2.


    . Chronic neurodegeneration induces type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progression. Glia. 2019 Jul;67(7):1254-1276. Epub 2019 Jan 25 PubMed.

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