Ghetti B, Schweighauser M, Jacobsen MH, Gray D, Bacioglu M, Murzin AG, Glazier BS, Katsinelos T, Vidal R, Newell KL, Gao S, Garringer HJ, Spillantini MG, Scheres SH, Goedert M. TMEM106B amyloid filaments in the Biondi bodies of ependymal cells. Acta Neuropathol. 2024 Nov 6;148(1):60. PubMed.

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  1. The conclusion that the Biondi bodies may contribute to the reduction in CSF production in aging, and possibly in age related neurodegenerative disease in which CSF clearance may be reduced, is certainly of interest. Another aspect that could be of interest is a potential link between Biondi bodies and the tight junctions that connect adjacent ependymal cells. A disruption of the TJ could lead to entry into the CSF of deleterious blood products with possible pathogenic relevance.

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  1. What’s Inside Those Mysterious Biondi Bodies? Hello, TMEM106B!