. Time Trends in the Incidence of Parkinson Disease. JAMA Neurol. 2016 Jun 20; PubMed.


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  1. What about the incidence of pesticide utilization? PD incidence is increased in farmers. It would be interesting to have information about the possible exposure to environmental factors, profession, etc., of the patients involved.

    Somebody born between 1915 and 1924 might have been working in a farm, or working with loads of fruits and vegetables sprayed with pesticides, in the 1950s, when DDT and other pesticides (even more harmful than the current ones) were used in huge quantities and without precaution.


    . The relation between type of farming and prevalence of Parkinson's disease among agricultural workers in five French districts. Mov Disord. 2011 Feb 1;26(2):271-9. Epub 2010 Dec 13 PubMed.

    View all comments by Meduri Geri
  2. We agree that new data should be collected about occupational exposures of the patients with incident Parkinson’ disease (PD) in our population. The study could be designed as a case-control study comparing patients with PD to age and sex-matched controls free of PD. We conducted a similar case-control study in the patients who developed PD in Olmsted County, Minnesota, in the time period 1976-1995, and we found a significant association with pesticide use in men (Frigerio et al., 2006). On the other hand, farming in general was not found to be significantly associated with the risk of PD in Olmsted County in that time period (Frigerio et al., 2005).

    We hope to be able to obtain funding for a similar study for the patients with onset in the 1996-2010 time interval.


    . Chemical exposures and Parkinson's disease: a population-based case-control study. Mov Disord. 2006 Oct;21(10):1688-92. PubMed.

    . Education and occupations preceding Parkinson disease: a population-based case-control study. Neurology. 2005 Nov 22;65(10):1575-83. PubMed.

    View all comments by Walter A. Rocca

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  1. A Rising Tide of Parkinson’s?