. tau Exon 10 expression involves a bipartite intron 10 regulatory sequence and weak 5' and 3' splice sites. J Biol Chem. 2002 Jul 19;277(29):26587-99. PubMed.

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Comments

  1. This is an interesting and thorough paper discussing the details of tau splicing regulation. However, it comes to the suprising, and probably erroneous conclusion that there is not a stem look structure at the exon 10 splice site, but rather, that the linear sequence of the hnRNA is what is important. While it is clear that linear sequence elements will be important in regulating tau splicing, the stem loop structure has already had predictive value as to where mutations may cause disease (Hutton 2000). In my view, these predictions of disease occurrence, outweigh the clear limitations of artificial in vitro biology.

    References:

    . "Missing" tau mutation identified. Ann Neurol. 2000 Apr;47(4):417-8. PubMed.

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