. Symptom onset in autosomal dominant Alzheimer disease: a systematic review and meta-analysis. Neurology. 2014 Jul 15;83(3):253-60. Epub 2014 Jun 13 PubMed.


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  1. As the authors clearly articulate, these findings have clear implications for prediction of age at onset for clinical research. In addition, these results reiterate previous reports that autosomal dominant mutations have a broad range of onset, even well into the over-65-year range often associated with sporadic AD. Finally, this report strongly suggests that gene-gene and possibly gene-environment interactions that are shared within families have a significant influence on age at onset of autosomal dominant Alzheimer’s disease.

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