. Striation is the characteristic neuritic abnormality in Alzheimer disease. Brain Res. 1998 Dec 7;813(2):329-33. PubMed.


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  1. The authors suggest that the neuritic striations they describe may disrupt the microtubule system and, thus, block fast axonal transport. This could be an important component of both the disrupted synapses as well as altered retrograde transmission of material via the microtubule network. Data such as these emphasize the importance of events in AD that do not require either cell death or the formation of frank neurofibrillary tangles.

  2. This is an interesting paper because it suggests a specific pathological pattern for dystrophic neurites. This information should help to understand the mechanism of the cytoskelatal abnormalities in AD.

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