. Spatial navigation deficit in amnestic mild cognitive impairment. Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4042-7. PubMed.


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  1. This is an interesting approach to the assessment of early diagnostic tests for AD. As for the MCI aspect of the study, I think it is a nice demonstration of deficits in spatial memory in amnestic MCI, which certainly would be consistent with the underlying construct. However, if one were to include spatial navigation relatively independently of spatial memory, then that would implicate another, non-memory, domain, and suggest amnestic multiple domain MCI. As I interpret the results, the authors are postulating the former rather than the latter. I think this is an interesting approach to early diagnosis, but I am not sure how practical it might be in a clinical setting. Nevertheless, as a proof of principle, it is an unique finding.

    View all comments by Ron Petersen
  2. This article confirms the results obtained by Ritter and the importance of spatial memory in amnestic MCI.


    . Topographical recognition memory sensitive to amnestic mild cognitive impairment but not to depression. Int J Geriatr Psychiatry. 2006 Oct;21(10):924-9. PubMed.

    View all comments by Mohammed Zaim

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