. Sleep and waking modulate spine turnover in the adolescent mouse cortex. Nat Neurosci. 2011 Nov;14(11):1418-20. PubMed.


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  1. Giulio Tononi's findings may or may not be related to the findings in humans of circadian Aβ levels. One hypothesis is that increasing spine and synaptic strength during wakefulness leads to increased Aβ production via increased synaptic activity. Conversely, decreased spine density and synaptic strength during sleep may decrease Aβ levels via decreased synaptic activity.

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  1. Sleep Trims Synaptic Spines in Adolescents