. Sept4, a component of presynaptic scaffold and Lewy bodies, is required for the suppression of alpha-synuclein neurotoxicity. Neuron. 2007 Feb 15;53(4):519-33. PubMed.


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  1. The authors have carried out a fundamental work on Septin, a scaffolding protein. It does play a dual role in the dopaminergic neurons by organizing the dopamine neurons for better neurotransmission and also protects the accumulation of pathological forms of synuclein.

    It would be even more precise to study the effect of septin on the oligomers (considered to be the toxic species in the filament formation) in the cell lines by its expression.This study indirectly speaks about the neuronal vulnerability and selective cell death of the dopaminergic neurons to a certain extent.

    View all comments by Bharathi Shrikanth Gadad

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  1. Dopamine Neurons Take the Fall When Scaffolding Collapses