. Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid-beta. Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):5063-8. PubMed.


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  1. This is an important study focusing on cerebrovascular dysfunction as a key target of Aβ pathogenic effects. Constantino Ladecola and colleagues have been studying for several years the role of oxidative stress in cerebral vessels, and more specifically, NADPH oxidase-dependent oxidant stress. In the present seminal work, they provide definitive evidence that CD36 scavenger receptor in brain endothelium is an absolute requirement for Aβ oxidant stress via NADPH oxidase. This establishes CD36 as a new important therapeutic target for Aβ-related neurovascular dysfunction.

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