Kantarci K, Przybelski SA, Lowe V, Weigand SD, Senjem ML, Ivnik RJ, Roberts RO, Geda YE, Boeve BF, Jack Jr CR.
s-Amyloid deposition, 1H MRS metabolites and cognitive function in a population-based cohort of cognitively normal elderly.
Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
Background: Understanding the relationship between imaging markers and cognitive function in the cognitively
normal elderly population may be useful in identifying the imaging markers of preclinical Alzheimer's disease (AD)
Objective: To determine the relationship between s-amyloid (As) deposition on PET and proton MR spectroscopy
(1H MRS) metabolites as potential preclinical markers of AD pathology.
Methods: We studied 311 cognitively normal older adults (median age = 80; range = 70-90) who participated in
the population-based Mayo Clinic Study of Aging (MCSA) from January 2009 through September 2010. The
participants underwent amyloid imaging with [11C]-Pittsburgh Compound B (PiB), single voxel 1H MRS from the
posterior cingulate gyrus and neuropsychometric testing. Associations between cognitive function, 1H MRS
metabolites and PiB retention were investigated. We adjusted for age, sex and education level in all analyses.
Results: Global cortical PiB retention ratio was associated with higher glial marker myoinositol/creatine
(mI/Cr) (r = 0.17; p = 0.003) and membrane integrity marker choline (Cho)/Cr (r = 0.13; p = 0.022) after adjusting for
age, sex and education. Higher PiB retention was associated with lower performance on the Trail Making Test Part
B (r = 0.13; p = 0.03), WAIS-R Digit Symbol (r = -0.12; p onclusion: 1H MRS metabolite markers of AD are associated with As deposition in cognitively normal elderly.
Whereas higher global PiB retention was associated with lower performance in naming, attention/executive
function measures, higher Cho/Cr ratio was associated with lower performance on memory, attention/executive
function and visual-spatial processing measures in cognitively normal elderly. These associations between 1H MRS
metabolite markers, PiB retention and cognition suggest that 1H MRS metabolites are related to the preclinical
pathological processes in the amyloid cascade influencing cognitive function.