. The role of amyloid-beta derived diffusible ligands (ADDLs) in Alzheimer's disease. Curr Top Med Chem. 2006;6(6):597-608. PubMed.


Please login to recommend the paper.


  1. Catalano et al. hypothesize that disruption of fibrils could result in an increase of soluble Aβ oligomers. I want to test this hypothesis in vivo, specifically that disrupting fibrils leads to increases in ADDLs that correlates with cognitive deficits in non-transgenic Long-Evans rats.

    My question is, What could I use that would disrupt and solubilize fibrils? I have heard of clioquinol, but I was wondering if there are other options that I am unaware of?

Make a Comment

To make a comment you must login or register.