Federoff HJ, Mhyre TR.
Reversal of misfolding: prion disease behavioral and physiological impairments recover following postnatal neuronal deletion of the PrP gene.
Neuron. 2007 Feb 1;53(3):315-7.
PubMed.
It would be interesting to see whether PDGF is also able to reverse the disease process if given during this window of opportunity. Kniazeva et al. (1997) have reported that PDGF is able to suppress PrP mRNA expression.
References:
Kniazeva M, Orman R, Terranova VP.
Expression of PrP mRNA is regulated by a fragment of MRP8 in human fibroblasts.
Biochem Biophys Res Commun. 1997 May 8;234(1):59-63.
PubMed.
Comments
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It would be interesting to see whether PDGF is also able to reverse the disease process if given during this window of opportunity. Kniazeva et al. (1997) have reported that PDGF is able to suppress PrP mRNA expression.
References:
Kniazeva M, Orman R, Terranova VP. Expression of PrP mRNA is regulated by a fragment of MRP8 in human fibroblasts. Biochem Biophys Res Commun. 1997 May 8;234(1):59-63. PubMed.
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