Villemagne VL, Ellis KA, Chetelat G, Bourgeat P, Jones G, Salvado O, Martins R, Ames D, Masters CL, Rowe CC.
Relation between Rates of Aβ Deposition, Apoe Genotype and Cognition: Results from-5 Year Longitudinal Study.
Human Amyloid Imaging Abstract. 2012 Jan 1;
Background: Longitudinal evaluation of ageing individuals is providing insight into the different factors leading to Alzheimer's disease (AD). In this study, we used longitudinal data from the AIBL cohort, to provide a better understanding of the relationship between Abdeposition and cognition in the development of AD.
Methods: One hundred and nineteen participants -74 elderly healthy controls (HC);9 Mild Cognitive Impairment (MCI) subjects; and6 mild AD patients - were evaluated at enrolment and8 and6 months later. On each visit, participants underwent neuropsychological examination, a MRI and a1C-PiB PET scan. Rates of change for Aβ deposition and cognitive decline were derived from the slope of the regression plots over-5 years and used in the correlational analysis.
Results: Aβ deposition (0.05±0.04 vs 0.01±0.03 SUVR/yr, pConclusions: Aβ deposition is associated with cognitive decline even in asymptomatic healthy controls. This supports the theory that Aβ deposition plays a fundamental role in the development of AD and suggests that to be effective, anti-Aβ therapy may need to be given early in the course of the disease, perhaps even before symptoms appear.