. Reduction of Abeta accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidyl-inositol kinase inhibitor wortmannin. FASEB J. 2001 Jan;15(1):16-18. Epub 2000 Nov 9 PubMed.


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  1. Wortmannin is too toxic to be used as a therapeutic, but the idea of using such inhibitors is important to be aware of.

  2. "An interesting paper which shows yet another way of reducing plaque load... as a result of the transgenic work, there are now many hopeful avenues for the drug industry and academics to look for Alzheimer treatments."

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