Clioquinol is a 8-hydroxyquinoline derivative and will bond with aluminum, another risk factor for Alzheimer's. Del Castilo et al., in their study of chromatin staining methods, reported that the "most suitable compounds for forming fluorescent Al chelates were 8-hydroxyquinoline, morin, nuclear fast red and purpurin". Thus the in-vivo imaging approach proposed by Opazo et a. may also image aluminum deposits as well as beta-amyloid.
References:
Del Castillo P, Llorente AR, Gómez A, Gosálvez J, Goyanes VJ, Stockert JC.
New fluorescence reactions in DNA cytochemistry. 2. Microscopic and spectroscopic studies on fluorescent aluminum complexes.
Anal Quant Cytol Histol. 1990 Feb;12(1):11-20.
PubMed.
Comments
Johns Hopkins University
This paper provides proof of concept that CQ may be used as an in vivo imaging agent for AD pathology.
Clioquinol is a 8-hydroxyquinoline derivative and will bond with aluminum, another risk factor for Alzheimer's. Del Castilo et al., in their study of chromatin staining methods, reported that the "most suitable compounds for forming fluorescent Al chelates were 8-hydroxyquinoline, morin, nuclear fast red and purpurin". Thus the in-vivo imaging approach proposed by Opazo et a. may also image aluminum deposits as well as beta-amyloid.
References:
Del Castillo P, Llorente AR, Gómez A, Gosálvez J, Goyanes VJ, Stockert JC. New fluorescence reactions in DNA cytochemistry. 2. Microscopic and spectroscopic studies on fluorescent aluminum complexes. Anal Quant Cytol Histol. 1990 Feb;12(1):11-20. PubMed.
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