. PTI-125 Reduces Biomarkers of Alzheimer's Disease in Patients. J Prev Alzheimers Dis. 2020;7(4):256-264. PubMed.


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  1. While interesting, the reason baseline and post-treatment CSF Aβ42 levels are so low in the analysis needs to be explained. See Kokkinou et al., 2021. How does Simufilam differ from LSD in structure?


    . Plasma and cerebrospinal fluid ABeta42 for the differential diagnosis of Alzheimer's disease dementia in participants diagnosed with any dementia subtype in a specialist care setting. Cochrane Database Syst Rev. 2021 Feb 10;2:CD010945. PubMed.

  2. Thanks for your comment. Aβ42 was measured using Invitrogen's ELISA kit. Different antibodies can produce very different results, even though all translate data to pg/mL. I can say that the R2 values for the standard curves for all ELISAs were 0.88 or higher. I cannot access this full paper—which ELISA plates were used? Simufilam is not LSD. That was plugged into a presentation once when we were not yet disclosing structure.

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