. A protein kinase, PKN, accumulates in Alzheimer neurofibrillary tangles and associated endoplasmic reticulum-derived vesicles and phosphorylates tau protein. J Neurosci. 1998 Sep 15;18(18):7402-10. PubMed.


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  1. Kinases that phosphorylate tau are of great interest for AD as tau hyperphosphorylation is a key pathological event in this disease.

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