. Proteasome inhibition causes nigral degeneration with inclusion bodies in rats. Neuroreport. 2002 Aug 7;13(11):1437-41. PubMed.

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  1. Proteasomal inhibition is thought to contribute to the pathophysiology of Parkinson's disease. The observations that proteasomal inhibition appears to recapitulate Parkinson's disease in a rat represents a potentially important advance for the field. It is particularly encouraging that the loss of dopaminergic neurons is associated with a corresponding increase in aggregated synuclein.

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