Proteasomal inhibition is thought to contribute to the pathophysiology of Parkinson's disease. The observations that proteasomal inhibition appears to recapitulate Parkinson's disease in a rat represents a potentially important advance for the field. It is particularly encouraging that the loss of dopaminergic neurons is associated with a corresponding increase in aggregated synuclein.
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Boston University School of Medicine
Proteasomal inhibition is thought to contribute to the pathophysiology of Parkinson's disease. The observations that proteasomal inhibition appears to recapitulate Parkinson's disease in a rat represents a potentially important advance for the field. It is particularly encouraging that the loss of dopaminergic neurons is associated with a corresponding increase in aggregated synuclein.
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