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  1. As Holmes and his colleagues have discovered, tumor necrosis factor-α plays a key role in Alzheimer's disease—although that role may be more due to its induction of peroxynitrites than to inflammation (Hikiji et al., 2000). Peroxynitrite damage is widespread in Alzheimer's disease (Smith et al., 1997). Many peroxynitrite scavengers have been found to protect against, ameliorate, and correct cognitive deficits in animal models of the disease. Indeed, employing peroxynitrite scavengers may open the door to the treatment of this disease.


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