. Progressive neuronal loss and behavioral impairments of transgenic C57BL/6 inbred mice expressing the carboxy terminus of amyloid precursor protein. Neurobiol Dis. 2006 Apr;22(1):10-24. PubMed.

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Comments

  1. In the normal human brain, there is are many beta stubs (C99) as alpha stubs. This is a fact that can be verified by a simple western blot. Why is mother nature stupid enough to make highly detrimental toxic APP-CTF in normal conditions?

    References:

    . Progressive decrease of amyloid precursor protein carboxy terminal fragments (APP-CTFs), associated with tau pathology stages, in Alzheimer's disease. J Neurochem. 2002 May;81(4):663-72. PubMed.

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