. Prevalence and incidence of beta-amyloid accumulation from cross-sectional and longitudinal [11C] PIB PET imaging. Human Amyloid Imaging 2010 Meeting Abstracts. 2010 April 9;


Background: We performed PET [11C] PIB scans on cognitive normal subjects in both a cross-sectional and longitudinal design to estimate the prevalence and incidence of Aβ plaques, as well as the rate of accumulation.

Methods: Cognitively normal (CDR 0) subjects (45 to 88 yrs) underwent one (n=241) or two (n=129; separated by 2.5±1.1 years) PET [11C] PIB scans. Binding Potential (BP) values and a global estimate of Aβ plaque deposition, the mean cortical BP (MCBP), were estimated in MRI-derived regions. The rate of Aβ accumulation was estimated from the change in BP per year.

Results: Using a threshold of MCBP >0.18, prevalence of Aβ plaques were seen to increase with age from 4.4% in the 50-59 decade to 30% in the 80-89 decade. Longitudinal analysis showed that 8 of the 110 subjects (7.3%) with a negative initial scan became positive on the second PIB scan yielding an incidence of 2.9%/yr. Subjects with at least one abnormal PIB scan (n=29) had a significantly higher rate of Aβ accumulation compared to the remaining subjects (0.034 BP/yr vs 0.008 BP/yr; pConclusions: [11C] PIB can detect accumulation of Aβ in cognitively normal subjects. These results suggest that combining longitudinal and cross-sectional Aβ imaging may characterize the onset and progression of a preclinical AD state to dementia.


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  1. Toronto: HAI Amyloid Imaging Conference Abstracts