. Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response. Nat Cell Biol. 1999 Dec;1(8):479-85. PubMed.


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  1. This is a nice cell biological study on AD. Perturbation at ER documented here is deeply related with all types of AD. Further investigation is welcome.

  2. This is an important paper as it reports a new PS1 function and suggests a mechanism for cellular damage of the PS1 FAD mutations.

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