. Presenile Alzheimer dementia characterized by amyloid angiopathy and large amyloid core type senile plaques in the APP 692Ala-->Gly mutation. Acta Neuropathol. 1998 Sep;96(3):253-60. PubMed.


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  1. There are at least three mutation sites in the APP sequence. They influence processing of APP to produce beta-amyloid protein in a different fashion. This is undoubtedly one of the papers that will contribute to our understanding of the biological effects of such mutations.

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  1. APP A692G (Flemish)