Illán-Gala I, Lleo A, Karydas A, Staffaroni AM, Zetterberg H, Sivasankaran R, Grinberg LT, Spina S, Kramer JH, Ramos EM, Coppola G, La Joie R, Rabinovici GD, Perry DC, Gorno-Tempini ML, Seeley WW, Miller BL, Rosen HJ, Blennow K, Boxer AL, Rojas JC. Plasma Tau and Neurofilament Light in Frontotemporal Lobar Degeneration and Alzheimer Disease. Neurology. 2021 Feb 2;96(5):e671-e683. Epub 2020 Nov 16 PubMed.
AlzBiomarker Database
Meta-Analysis
- AD vs CTRL : tau-total (Plasma and Serum)
- CTRL vs AD : tau-total (Plasma and Serum)
- FTD vs AD : tau-total (Plasma and Serum)
- PSP vs AD : tau-total (Plasma and Serum)
Curated Study Data
| Biomarker (Source) |
Cohort (N) |
Measurement Mean ± SD |
Method; Assay Name; Manufacturer |
Diagnostic Criteria |
|---|---|---|---|---|
| tau-total (Plasma) |
AD (43) |
2.52 ± 0.72 pg/mL § |
SIMOA; Other/Not Specified; Quanterix |
Dubois et al., 2014 |
| tau-total (Plasma) |
CTRL- CNC (55) |
2.41 ± 0.65 pg/mL § |
SIMOA; Other/Not Specified; Quanterix |
|
| tau-total (Plasma) |
FTD- bvFTD (43) |
2.54 ± 1.02 pg/mL § |
SIMOA; Other/Not Specified; Quanterix |
Rascovsky et al., 2011 |
| tau-total (Plasma) |
FTD- nfvPPA (28) |
2.21 ± 0.75 pg/mL § |
SIMOA; Other/Not Specified; Quanterix |
Gorno-Tempini et al., 2011 |
| tau-total (Plasma) |
FTD- svPPA (18) |
2.35 ± 0.84 pg/mL § |
SIMOA; Other/Not Specified; Quanterix |
|
| tau-total (Plasma) |
PSP (36) |
2.71 ± 1.14 pg/mL § |
SIMOA; Other/Not Specified; Quanterix |
Litvan et al., 1996 |
§ Data supplied to Alzforum by author
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