Startin CM, Ashton NJ, Hamburg S, Hithersay R, Wiseman FK, Mok KY, Hardy J, Lleó A, Lovestone S, Parnetti L, Zetterberg H, Hye A, LonDownS Consortium, Strydom A. Plasma biomarkers for amyloid, tau, and cytokines in Down syndrome and sporadic Alzheimer's disease. Alzheimers Res Ther. 2019 Mar 21;11(1):26. PubMed.
AlzBiomarker Database
Meta-Analysis
- AD vs CTRL : Aβ40 (Plasma and Serum)
- CTRL vs AD : Aβ40 (Plasma and Serum)
- AD vs CTRL : Aβ42 (Plasma and Serum)
- CTRL vs AD : Aβ42 (Plasma and Serum)
- AD vs CTRL : tau-total (Plasma and Serum)
- CTRL vs AD : tau-total (Plasma and Serum)
Curated Study Data
Biomarker (Source) |
Cohort (N) |
Measurement Mean ± SD |
Method; Assay Name; Manufacturer |
Diagnostic Criteria |
---|---|---|---|---|
Aβ40 (Plasma) |
AD (27) |
172.89 ± 82.41 pg/mL § |
SIMOA; Human Neurology 3-Plex A assay (N3PA); Quanterix |
McKhann et al., 1984 |
Aβ40 (Plasma) |
CTRL- CNC (27) |
148.39 ± 75.75 pg/mL § |
SIMOA; Human Neurology 3-Plex A assay (N3PA); Quanterix |
|
Aβ42 (Plasma) |
AD (27) |
12.63 ± 4.07 pg/mL § |
SIMOA; Human Neurology 3-Plex A assay (N3PA); Quanterix |
McKhann et al., 1984 |
Aβ42 (Plasma) |
CTRL- CNC (27) |
15.72 ± 7.43 pg/mL § |
SIMOA; Human Neurology 3-Plex A assay (N3PA); Quanterix |
|
tau-total (Plasma) |
AD (27) |
2.27 ± 4.54 pg/mL § |
SIMOA; Human Neurology 3-Plex A assay (N3PA); Quanterix |
McKhann et al., 1984 |
tau-total (Plasma) |
CTRL- CNC (27) |
2.38 ± 2.53 pg/mL § |
SIMOA; Human Neurology 3-Plex A assay (N3PA); Quanterix |
§ Data supplied to Alzforum by author
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