. PiB retention and neuropsychological test performance among cognitively normal men. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;


Retention of the amyloid ligand, Pittsburgh Compound B (PiB) occurs in cognitively normal, elderly individuals. What is less clear is the extent to which there is a relationship between the extent of PiB retention and performance on neuropsychological tests among cognitively normal individuals who are, on average, younger than 65 years. We report here the results of the analysis of PiB data from a group of 22 young (age = 61.5 years) cognitively normal men (mean education = 15.9 years) who are participating in a study of amyloid deposition and cardiovascular risk factors.

PiB data were reconstructed and corrected for attenuation, scatter, and decay. Regions-of-interest were applied to obtain regional time-activity data and analyzed to obtain measures of the standardized uptake value. The SUV measure was normalized to the cerebellum. The scores from the neuropsychological test battery were reduced to T-scores adjusting for age, education, sex and race. The T-scores were then converted into domain and global impairment scores using standard methods. 16/22 of the subjects (73%) had global impairment ratings in the normal range; the remainder scored in the Borderline range.

The performance of the subjects on measures of cognitive speed were significantly associated with amyloid deposition in the Anterior Cingulate (rho = 0.45), Frontal Cortex (rho = 0.40) and Lateral Temporal Cortex (rho = 0.39). The highest level of PiB retention was found in the subjects classified as performing in the Borderline range. There was no association between performance in the Speed Domain and overall classification of PiB gpositiveh. The results of this initial analysis demonstrate that it is possible to find links between the relative amount of PiB retention, and performance on measures of cognitive function. The findings are consistent with prior work that reported early amyloid deposition in anterior cortical regions.


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  1. Miami: HAI Amyloid Imaging Conference Abstracts