Li YM, Xu M, Lai MT, Huang Q, Castro JL, DiMuzio-Mower J, Harrison T, Lellis C, Nadin A, Neduvelil JG, Register RB, Sardana MK, Shearman MS, Smith AL, Shi XP, Yin KC, Shafer JA, Gardell SJ. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1. Nature. 2000 Jun 8;405(6787):689-94. PubMed.

Comments

- Benjamin Wolozin
  Boston University School of Medicine
- Posted: 03 Jul 2002
Obiously important.

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- Hiroshi Mori
  Osaka City University Medical School
- Posted: 03 Jul 2002
Further evidence is provided here to prove that PS1 is gamma-secretase. The next proof desired is a direct one.

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- John Hardy
  Institute of Neurology, UCL
- Posted: 03 Jul 2002
Now proven almost beyond reasonable doubt: presenilin = gamma secretase. The three papers almost establish beyond reasonable doubt that presenilins are the long-sort after gamma secretases. The questions that remain include what are the other components of the macromolecular complex which they are part of?

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- Richard Mayeux
  Columbia University
- Posted: 03 Jul 2002
Role of PS1/2 as interactive with gamma secretase.

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