. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1. Nature. 2000 Jun 8;405(6787):689-94. PubMed.


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  1. Obiously important.

  2. Further evidence is provided here to prove that PS1 is gamma-secretase. The next proof desired is a direct one.

  3. Now proven almost beyond reasonable doubt: presenilin = gamma secretase. The three papers almost establish beyond reasonable doubt that presenilins are the long-sort after gamma secretases. The questions that remain include what are the other components of the macromolecular complex which they are part of?

  4. Role of PS1/2 as interactive with gamma secretase.

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