. Patterns of amyloid deposition distinguish non-demented Parkinson’s disease from normal aging. Human Amyloid Imaging 2010 Meeting Abstracts. 2010 April 9;


In a previous study, we found that non-demented patients with Parkinson’s disease (PD) did not differ from normal controls (NC) in average global PiB binding, but focal cortical PiB retention was observed in many PD subjects and in all demented patients with PD. In this study, we tested whether the overall burden and spatial distribution of amyloid deposits differed in non-demented PD compared to healthy controls.

Twenty non-demented PD patients (age 70±7 years) and 70 NC (aged 74±8 years) underwent PiB PET, highresolution MR imaging, Freesurfer processing, and partial volume correction. Cortical PiB DVR values in ROI were left-right averaged. A linear stepwise discriminant analysis initially identified a subset of 7 ROIs from a pool of 35, a linear combination of which significantly discriminated the two groups (pThe discriminant coefficients indicated higher DVR values in parahippocampal, post-central and rostral anterior cingulate ROIs reflecting PD status, whereas higher DVR values in posterior cingulate, lateral occipital, temporal pole and amygdala were indicative of NC status. Non-partial volume-corrected PET data yielded slightly weaker results though still significant. We also found significant relations of discriminant scores to measures of motor impairment in PD (Hoehn & Yahr, UPDRS). These results suggest that PD patients and NC subjects can be reliably distinguished by different patterns of amyloid accumulation.


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  1. Toronto: HAI Amyloid Imaging Conference Abstracts