Koide T, Ohtake H, Nakajima T, Furukawa H, Sakai K, Kamei H, Makifuchi T, Fukuhara N.
A patient with dementia with Lewy bodies and codon 232 mutation of PRNP.
Neurology. 2002 Nov 26;59(10):1619-21.
PubMed.
An interesting and provocative paper. If the M232R mutation is pathogenic, then this suggests that DLB may be a alternative expression of prion disease. It is worth noting that Ghetti has published (in abstract form only) that other prion mutations have both tangles and Lewy bodies.
Comments
Institute of Neurology, UCL
An interesting and provocative paper. If the M232R mutation is pathogenic, then this suggests that DLB may be a alternative expression of prion disease. It is worth noting that Ghetti has published (in abstract form only) that other prion mutations have both tangles and Lewy bodies.
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