. Overexpression of wild-type murine tau results in progressive tauopathy and neurodegeneration. Am J Pathol. 2009 Oct;175(4):1598-609. PubMed.


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  1. Conditions under which an abnormality in tau processing could lead to neuronal degeneration are of great interest because of their potential implications for the role of tau in human neurodegenerative disease. This paper describes one set of conditions in which tau abnormalities appear to lead directly to neuronal degeneration.

  2. This is a nice model with a tauopathy in the absence, apparently, of tau filament formation. This complements the previously generated BAC human tau transgenic mice by Peter Davies and colleagues. Following their line of investigation, it would be interesting to determine whether crossing a conventional human tau transgenic strain with this new BAC murine tau transgenic model causes a more pronounced or an ameliorated phenotype.

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