. Overexpression in neurons of human presenilin-1 or a presenilin-1 familial Alzheimer disease mutant does not enhance apoptosis. J Neurosci. 1998 Dec 1;18(23):9790-9. PubMed.


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  1. It is important to clarify the issue of PS1 involvement in apotosis, especially since many people in the field work under the assumption that PS apotosis is involved in AD. The data in this paper is not consistent with the theory that PS apotosis is important in AD

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