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Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School
Overall, I think this is an important step forward in validating the preclinical staging framework in a well-characterized sample drawn from a community-dwelling cohort. The designation of additional categories is useful to provide a classification scheme for all "normals," but I think it will be important to learn more about the SNAP group in terms of other pathologies (cerebrovascular, other neurodegenerative diseases, hippocampal sclerosis, etc). Ultimately, the question is whether the Stage 1-3 preclinical framework is useful in predicting likelihood of decline towards MCI and AD dementia, for use in secondary prevention and very early intervention trials.
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