Saykin AJ, Wishart HA, Rabin LA, Santulli RB, Flashman LA, West JD, McHugh TL, Mamourian AC. Older adults with cognitive complaints show brain atrophy similar to that of amnestic MCI. Neurology. 2006 Sep 12;67(5):834-42. PubMed.

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  1. I think this is an important paper reporting on a well-conducted study.
    Although cross-sectional, the results imply a subtle continuum from
    cognitive complaints through to mild cognitive impairment and on to
    Alzheimer disease. Using a good-sized cohort of 40 subjects with
    cognitive complaints, 40 MCI subjects, and 40 controls, Saykin and
    colleagues used both voxel-based methods and region-of-interest outlining to show
    that relative to the control group, the MCI group had lower hippocampal
    volumes and lower grey matter densities in medial temporal lobe and
    elsewhere; importantly, they also showed that the group with cognitive
    complaints (but without cognitive deficits to meet MCI criteria) had
    hippocampal and grey matter volumes intermediate between the two groups.
    The paper therefore provides further, albeit circumstantial, evidence
    that structural changes—and in particular medial temporal lobe grey
    matter losses—may be detectable before cognitive deficits become
    manifest. It also reminds us that in certain settings, cognitive
    complaints should be taken seriously even when formal neuropsychometry
    appears within normal limits.

    View all comments by Nick Fox

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