. Observations in APP bitransgenic mice suggest that diffuse and compact plaques form via independent processes in Alzheimer's disease. Am J Pathol. 2011 May;178(5):2286-98. PubMed.


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  1. That compact and diffuse plaques develop by independent mechanisms has been suggested in the first paper describing APPsw mutant APP23 mice: These mice develop almost exclusively compact plaques, whereas APP22 mice expressing APPsw together with V717I express mostly diffuse plaques (that do not mature to compact plaques).


    . Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology. Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):13287-92. PubMed.

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