. A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase. Nat Genet. 1998 Feb;18(2):159-63. PubMed.

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  1. Perhaps they are right that this provides a useful model but they have not shown yet how useful it can be.

  2. Reactive oxygen species (ROS) have been implicated in a wide range of degenerative processes including amyotrophic lateral sclerosis, ischemic heart disease, Alzheimer disease, Parkinson disease and aging(1-5). The present study strongly suggests the significant function of SOD in neurodegeneration.

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