Kimberly WT, Esler WP, Ye W, Ostaszewski BL, Gao J, Diehl T, Selkoe DJ, Wolfe MS.
Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s).
Biochemistry. 2003 Jan 14;42(1):137-44.
PubMed.
Interesting study that optimizes an in vitro gamma-secretase cleavage assay. While the results have been reported elsewhere mostly from intact cells, this is a thorough study with important confirmations using a different system.
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Interesting study that optimizes an in vitro gamma-secretase cleavage assay. While the results have been reported elsewhere mostly from intact cells, this is a thorough study with important confirmations using a different system.
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