. Nordihydroguaiaretic acid potently breaks down pre-formed Alzheimer's beta-amyloid fibrils in vitro. J Neurochem. 2002 May;81(3):434-40. PubMed.


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  1. Nordihydroguaiaretic acid (NDGA) may be posotively considered as another therapeutic or diagnostic tool for AD. Based on current issue, an interest is evoked on the effect of NDGA on non-fibrillar Abeta but oligomeric Abeta.

  2. Please see the following comments related to this article: Alzheimer's disease and amyloid beta protein Koudinov AR et al Science online,> Published 25 June 2002 [ Full Text ] Alzheimer’s anti-amyloid vaccination and statins: two approaches, one dogma. The time for change. Koudinov and Koudinova BMJ 20 March 2002 [ Full Text ]

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