Phinney AL, Calhoun ME, Wolfer DP, Lipp HP, Zheng H, Jucker M.
No hippocampal neuron or synaptic bouton loss in learning-impaired aged beta-amyloid precursor protein-null mice.
Neuroscience. 1999;90(4):1207-16.
PubMed.
This seems to be a well done study that has implications for the normal function of a beta. A question that seems to be left open is whether similar results would be obtained with a conditional null mouse.
Comments
Osaka City University Medical School
It is important to know despite no difference in synaptic bouton and behavior between APP null and wild mice.
Banner Research Institute
This seems to be a well done study that has implications for the normal function of a beta. A question that seems to be left open is whether similar results would be obtained with a conditional null mouse.
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