. New Perspectives for the Rescue of Cognitive Disability in Down Syndrome. J Neurosci. 2015 Oct 14;35(41):13843-52. PubMed.


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  1. It’s amazing to me that we are now talking about treating cognitive disabilities associated with Down’s syndrome. The data presented at SfN give hope that there are a number of potential therapies that might treat Down’s syndrome phenotypes, as well as several time points when intervention might be effective. Animal models have provided, and will continue to provide, a wealth of information to help us understand how particular therapies work. To me, the big hurdle is to show how and where potential therapies are working at the cellular and molecular levels. I do not believe one therapy will be able to overcome all of the cognitive phenotypes. It will be important to test the impact of individual components of combination treatments to find their effects. It is also important to have sufficient funding to continue the necessary basic science research. Then well-designed clinical trials will be important to understand the impact that potential treatments might have on individuals with Down’s syndrome.

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