. Neuropathologic substrate of mild cognitive impairment. Arch Neurol. 2006 Jan;63(1):38-46. PubMed.


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  1. This careful study reinforces the idea that amnesic MCI is an early stage of the same disease process that occurs in Alzheimer's disease, and thus supports the idea that early intervention studies should be targeted at this population. On the other hand, the idea that an individual "converts" from amnesic MCI to AD becomes a little difficult to see as a unique pathophysiological event.

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