Thorsell A, Bjerke M, Gobom J, Brunhage E, Vanmechelen E, Andreasen N, Hansson O, Minthon L, Zetterberg H, Blennow K. Neurogranin in cerebrospinal fluid as a marker of synaptic degeneration in Alzheimer's disease. Brain Res. 2010 Nov 29;1362:13-22. Epub 2010 Sep 25 PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)		 Cohort
(N)		 Measurement
Mean ± SD		 Method;
Assay Name;
Manufacturer		 Diagnostic
Criteria
Aβ42
(CSF)		 AD
(10)		 338 ± 131
pg/mL		 ELISA;
Innotest;
Innogenetics		 McKhann et al., 1984
Aβ42
(CSF)		 CTRL-
CNC
(11)		 759 ± 224
pg/mL		 ELISA;
Innotest;
Innogenetics
tau-p181
(CSF)		 AD
(10)		 117 ± 67
pg/mL		 ELISA;
Innotest;
Innogenetics		 McKhann et al., 1984
tau-p181
(CSF)		 CTRL-
CNC
(11)		 47 ± 11
pg/mL		 ELISA;
Innotest;
Innogenetics
tau-total
(CSF)		 AD
(10)		 801 ± 591
pg/mL		 ELISA;
Innotest;
Innogenetics		 McKhann et al., 1984
tau-total
(CSF)		 CTRL-
CNC
(11)		 276 ± 83
pg/mL		 ELISA;
Innotest;
Innogenetics

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This paper appears in the following:

News

  1. New Biomarkers? Synaptic Proteins in Spinal Fluid Predict Cognitive Decline
  2. At AAIC, Researchers Debate Neurogranin's Measure as a Marker
  3. Paper Alert: Longitudinal Data Support CSF Neurogranin as an Early Synaptic Marker of Alzheimer’s Disease

AlzBiomarker

  1. AD vs CTRL : Aβ42 (CSF)
  2. CTRL vs AD : Aβ42 (CSF)
  3. AD vs CTRL : tau-p181 (CSF)
  4. CTRL vs AD : tau-p181 (CSF)
  5. AD vs CTRL : tau-total (CSF)
  6. CTRL vs AD : tau-total (CSF)