. Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Aβ aggregation in the 5XFAD mouse model of Alzheimer's disease. Neurobiol Aging. 2012 Jan;33(1):196.e29-40. PubMed.


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Research Models

  1. 5xFAD (C57BL6)
  2. Trem2 KO (Colonna) x 5XFAD


  1. Intraneuronal Aβ: Was It APP All Along?