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Bacskai BJ, Frosch MP, Freeman SH, Raymond SB, Augustinack JC, Johnson KA, Irizarry MC, Klunk WE, Mathis CA, Dekosky ST, Greenberg SM, Hyman BT, Growdon JH. Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case report. Arch Neurol. 2007 Mar;64(3):431-4. PubMed.
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Arizona Alzheimer's Consortium
This case report demonstrates a correlation between PIB retention in the living human brain and amyloid pathology at autopsy. It provides further support for the possibility of using this imaging technique to detect and track fibrillar amyloid pathology in the living human brain. Future studies will determine the extent to which PIB and other imaging techniques could be used in the diagnosis, preclinical detection, and tracking of Alzheimer disease and the evaluation of promising amyloid-modifying therapies.View all comments by Eric M. Reiman
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